Potkay Biomedical & Microsystems Research Lab
The Potkay Biomedical & Microsystems Research Lab works collaboratively with Michigan Medicine and the VA Ann Arbor Healthcare System to develop artificial lung technologies. Our work applies microfluidic and microsystem approaches to enhance device performance compared to the current state of the art, hollow fiber artificial lung designs.
Artificial Organs, Microfluidic Artificial Lungs, Bio-MEMS and Microfluidics, Bio-Micro Nanotechnology and Molecular Engineering, Biomedical Computation and Modeling, Biomembranes, Tissue Engineering and Biomaterials, Medical Microsystems, Implantable Sensors, Micro Gas Chromatography Devices and Systems
A high-resolution Asiga MAX X27 UV digital light processing (DLP) 3D printer and custom photopolymerizable polydimethylsiloxane (PDMS) resin were used to rapidly manufacture small-scale μALs via vat photopolymerization (VPP).
This work presents the highest density of 3D printed microchannels in a single device, one of the highest CO2 transfer efficiencies of any artificial lung to date, and a promising approach to translate μALs one step closer to the clinic.
Congratulations to Elyse Fleck and Andrew Zhang for both hosting oral presentations at the 2023 ASAIO Conference. Elyse presented "Toward a Biocompatible 3D Printing Resin for Microfluidic Organ Models". Andrew presented "Automated PDMS Engraving and Assembly of a Prototype Microfluidic Artificial Lung" and "Toward a Wearable Extracorporeal CO2 Removal System with Integrated Exhaust Gas CO2 Sensing" as well as a poster for "Toward automatic control of arterial blood PaCO2 using artificial lung exhaust gas CO2 as a surrogate". The team members collaborated on an abstract and poster: "Toward 3D-Printed Microfluidic Artificial Lungs with Complex Biomimetic Geometries".
Congratulations to Navid Shaikh and Elyse Fleck for both receiving 2022 ASAIO Oral Abstract Awards! Navid presented "Acute In Vivo Testing of a Portable Controller to Automate CO2 Removal in Artificial Lungs". Elyse presented 3 orals: "3D Printed, Small-Scale Microfluidic Artificial Lung," "Characterization of Stereolithography 3D Printing Resins For Microfluidic Artificial Lung Applications," and, "Toward a Blood-Compatible, 3D Printing Resin For Microfluidic Artificial Organs."
